Enfamil Enspire Vs Similac Pro Advance: Which is Better

It would be great if babies could talk and decide what they wanted. That way, the worries parents usually have about what infant formula their babies need will be a thing of the past.

However, that’s not the case. Babies cannot decide their feeding pattern or what they want to eat. So, the burden is on the parent to help figure out what would be ideal for them.

For that reason, the comparison – Enfamil Enspire vs Similac pro advance comes in handy.

Picking the preferred formula for your baby gets tedious many times. You could walk down the aisles of a grocery store and still see several products you need to decide on.

When it comes to infant formula, two good brands stand out: Enfamil and Similac.

So, which infant formula should a parent get? Is Enfamil enspire or Similac pro advance?

These two brands have become household names with their baby formula products. No wonder Enfamil Enspire and Similac Pro Advance come highly recommended. I have noticed that parents usually have issues deciding on which products to purchase.

So, I will be helping you make concrete decisions in that light as you look to give your baby the proper nutrients needed for them to thrive.

Enfamil Enspire Revive

Enfamil Enspire Infant Formula with Immune-Supporting Lactoferrin, Brain Building DHA, 5 Nutrient Benefits in 1 Formula, Our Closest Formula to Breast Milk, Non-GMO, Powder Refill Box, 30 Oz

  • Nonfat milk, lactose, vegetable oil, whey protein-lipid concentrate.
  • Galactooligosaccharides and polydextrose probiotics.
  • MFGM and Lactoferrin for cognitive development and immunity

Enfamil Enspire formula stands as an inspired way to nourish. It is the closest formula to breast milk, as lactoferrin is significant. Lactoferrin is a crucial component of colostrum and breastmilk that provides immune support and aids intestinal development.

Enfamil Enspire has other vital elements such as MFGM that encourages mental development, Omega 3 DHA, and choline, which are brain support nutrients. DHA is very critical for the eyes and nervous system of your child.

Enfamil Enspire has been designed with a unique blend to provide immune support and improve digestive health. The formula can aid the growth of beneficial bacteria through the digestive channel, where a significant part of your baby’s immune system is.

Enspire is a formula designed to provide complete nutrition for your baby through an entire course of twelve months.

Similac Pro Advance Revive

Similac Pro-Advance® Infant Formula, with 2′-FL HMO for Immune Support, Non-GMO, Baby Formula, Powder, 30.8 oz

  • Nonfat milk, lactose, whey protein concentrate, high-oleic and safflower oil.
  • 2’-FL HMO probiotics.
  • OptiGRO blend of DHA, Lutein, and Vitamin E for eye and brain.

The Similac Pro Advance baby formula is natural and close to breast milk. The reason is human milk oligosaccharide, a significant component in human milk. Human milk oligosaccharide aids immune support by making immune cells produce protective proteins in the same measure as the breastfed baby. The Pro Advanced is also the first infant formula without artificial growth hormones.

This formula has its unique blend of DHA that aids brain nourishment, lutein to aid the eyes’ health, and vitamin E, which helps with overall growth and development. All these nutrients are in breastmilk.

This formula contains no Palm Olein oil. Baby food without Palm Olein oil is known to ease your baby’s stooling process. The no Palm Olein bend of the Pro Advance formula aids calcium absorption. Similac Pro advance is one formula chosen by moms all around.

ALSO READ: Nutramigen Ready to Feed Vs Powder : Which Is Better

Enfamil Enspire vs Similac pro advance – What’s the Difference?

Both Enfamil Enspire vs Similac Pro Advance are gentle formulas and as close to the breastmilk as possible. So, what edge does one have over the other, and which product has that edge?

We’ll be comparing the ingredient quality, nutritional values, special features, potential issues, and the recommendations of each product to decide on which formula is ideal for your baby.

So, let’s get right into it.

Ingredient Quality

Enfamil Enspire has its primary ingredients: non-fat milk, lactose, protein-lipid concentrates, and vegetable oil.

These ingredients are of outstanding quality. While some other baby formulas use corn syrup that is very high in calories and hard to digest, Enfamil uses components that form a significant part of natural milk.

Enfamil also has some polysaccharides in real breast milk, making it ideal for your baby to digest. It also does not use any GMO ingredients that could cause issues.

On the other hand, Similac Pro Advance has primary ingredients like non-fat milk, lactose, and protein concentrate. These ingredients help your baby’s nutrition. The formula also has other components, soy oil, coconut oil, and safflower oil, to improve the formula’s form, flavor, and texture.

The Similac Pro Advance formula has in its claim extensive years of research that has brought about its production. The milk is as relatively close to breast milk because of polysaccharides.

ALSO READ: Nutramigen vs Elecare: Which is Better


Both baby formulas have very similar nutritional content. The differences in the values they offer are very marginal. So, they both excel in nutritional content. Enfamil Enspire provides more carbohydrates and protein, while the Similac Pro Advance provides higher fat and linoleic acid. Both formulas are ideal for the growth and development of your baby in the area of nutrition.


The Enfamil Enspire has unique features, including lactoferrin, MFGM, and probiotics. Probiotic is a combination of galactooligosaccharides and polydextrose, and they aid your baby’s digestive health. The MFGM helps with cognitive development, and the lactoferrin helps to boost the immune system.

The Similac Pro Advance, on the other hand, has 2’-FL HMO and OptiGRO blend. The 2’-FL HMO is in breastmilk, and it is pivotal for the digestive health and immunity of your baby. The OptiGRO blend contains DHA, Lutein, and Vitamin E for eye and brain development and the overall growth of your baby.

Potential Side Effects

These formulas are generally gentle for babies. However, they both contain lactose that could be difficult to digest for some babies. Such conditions are called lactose intolerance in babies. So, if your baby has lactose intolerance, you should avoid both formulas.

Furthermore, if your baby is allergic to cow’s milk or soy, I recommend you stay away from these formulas. Enfamil Enspire and Similac Pro Advance contain cow’s milk proteins and soy which can cause fussiness and irritation to your baby.

Therefore, go for hypoallergenic infant formulas like Enfamil Nutramigen and Similac Alimentum.

ALSO READ: Alimentum Powder Vs Ready to Feed: Which is Better?

Recommendations on Enfamil Enspire or Similac Pro Advance

Similac Pro Advance is highly recommended and backed by extensive years of research. In addition, the unique feature of the OptiGRO blend of this formula also aids eye and brain development.

For non-GMO options, Choose Enfamil Enspire if you want a formula for immune and cognitive development.

The similarity between Enfamil Enspire and Similac Pro Advance

  1. Lactose, whey protein concentrate, and nonfat milk are all included in both formulas.
  2. Choline, iron, lutein, DHA, and vitamin E are present.
  3. Coconut oil may be present.
  4. Both formulations are non-GMO and Kosher.

Formula Similar to Similac Pro Advance

There are some alternative baby formulas that you can choose; they provide the perfect nutritional formula to help the growth of your newborn.

Just as Similac Pro Advance, these formulas blend DHA, prebiotics, and comfort proteins that are easy for your babies’ tiny tummies to digest. They are Gluten-free, Non-GMO, and the closest formula to breastmilk.

They include, but are not limited to;

  1. Similac NeoSureNestlé NAN SUPREMEpro 1
  2. Baby’s Only Organic Premium Dairy
  3. Nestle Nan Pro
  4. Burt’s Bees Baby Organic

Enfamil Vs Similac: Which Is Better

It’s hard to choose between Enfamil vs Similac pro advance. Each has its own set of advantages and disadvantages.

Enfamil, for instance, offers more options if you want your baby’s milk to contain less sugar. On the other hand, Similac provides a variety of lutein-rich products without using palm olein oil, which some babies are sensitive to.

The Enfamil Infant formula provides nourishment for your baby and aid in brain development. Again, Enfamil Gentlease reduces tummy trouble, which helps to reduce gas, spit-ups, and crankiness in your child.

Similac Advance aids in brain and eye development and growth; the Similac Pro Advance also provides daily nutrition your bay needs.

Choosing the right formula is entirely dependent on your baby’s digestive health. You can decide whether to use Enfamil or Similac through trial and error and then select the formula that addresses most of your baby’s digestion problems!

Can I Use Similac and Enfamil at The Same Time?

You can combine Similac and Enfamil if you feel it will be okay with your baby. What matters most is how your baby’s stomach reacts to the mixture.

Using different brands of the same kind of formula is okay. Just watch out for any change in the stool and crankiness of your baby. But, again, you should check the pediatrician before changing or combining formula milk.

ALSO READ: Similac Soy Vs Enfamil Soy

Is it okay to Switch from Similac to Enfamil?

Contrary to what many parents believe, switching formula brands won’t make their baby fussy or cause stools to change. You can combine different brands of the same kind of formula if you think your baby will respond better to a mixture of more than one brand.

Conclusion on Enfamil Enspire vs Similac Pro Advance

Enfamil Enspire vs Similac Pro Advance – Ultimately, whatever baby formula you choose depends on your baby’s preference and yours too. You will also have to consider FDA requirements.

We have shown you the benefits of the Similac Pro Advance and the Enfamil Enspire, so feel free to follow our guidelines. Then, you can decide on the best pick for your baby.


7 Best Similac Alternative Formulas: https://babyproductslab.com/best-similac-alternative/

Should You Mix or Switch Between Baby Formula Brands: https://www.verywellfamily.com/mixing-baby-formula-brands-2634531

Show More

Related Articles

Leave a Reply

Your email address will not be published. Required fields are marked *